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In liquid nitrogen as low as -196°C, is the sealing film a protection or a threat?

Publish Time: 2024-09-02     Origin: Site

During the process of cell cryopreservation, some experimenters choose to wrap the mouth of the cryopreservation tube with sealing film to enhance the sealing. However, this is actually a common misunderstanding.




The sealing film is not suitable for ultra-low temperature environments, especially liquid nitrogen environments with temperatures as low as -196°C. Under such extreme conditions, the sealing film is prone to cold shrinkage and embrittlement, causing fragments to fall off. Not only does it fail to protect, it may also cause contamination problems.


Why is it not recommended to use parafilm for cell cryopreservation?





· Risk of material denaturation

The sealing film will degenerate, loosen or even break when stored in a -80°C refrigerator for a long time. When stored in a liquid nitrogen tank, the risk of degeneration and shedding is greater, which may contaminate the liquid nitrogen.

· Operational interference

During cell recovery, loose or peeling parafilm may affect experimental operations. If the sealing film falls into the water bath, it also increases the risk of plastic waste and microbial contamination.

·Sealing film size problem

Laboratories usually do not have specially adapted sealing films for cryovials, so wrapping them is often inappropriate and makes the operation more difficult.

· Save money and time

In the long run, this operation is a waste of time and materials. If more than 20,000 tubes of cells are frozen and each tube is wrapped with a sealing film, the accumulated length of the sealing film may be enough to circle the earth 1/10,000 times!

· Space issues

After wrapping the sealing film, the freezing tubes in the freezing box will appear too crowded, making it difficult to put the tubes into the freezing box, affecting operating efficiency.


Summary of experimental experience

Years of practice have shown that cryopreservation tubes without a sealing film can also ensure the sealing of the cryopreservation solution without increasing the risk of contamination or affecting the safety of the cryopreservation tube.



Tips for using cryovials

Before placing the cryovials into the programmed cooling box, it is recommended to lightly tighten the caps. This can prevent liquid nitrogen from entering the tube due to the slight shrinkage of the gap in the tube cover after cryopreservation, thereby reducing the risk of bloating and bursting during cell recovery.


Aijin Cryotube



At the same time, choosing the right cryovial is also crucial. Aijin cryopreservation tubes are made of imported medical-grade polypropylene (PP) and can be used for high-temperature and high-pressure sterilization. They can be used stably in the temperature range of -196°C to 121°C, ensuring the safety of cell cryopreservation. In addition, Aijin cryovials are pyrogen-free, endotoxin-free, DNase/RNase-free, and have been sterilized by electron beam, which can effectively ensure the reliability of experimental results.



Aijin cryopreservation tubes are available in a variety of capacity specifications, and the boxes are in compliance with SBS standards, which can meet different experimental needs. The product production environment is strictly controlled in a 100,000-level dust-free workshop to ensure product consistency and stability. In general, choosing the right cryogenic tube can not only effectively protect your samples, but also make your experimental operations more efficient and safer.

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